Version: 8.0.0
Date: Tue Jan 28 2025
Tial1
Rattus norvegicusRGD:1595845
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Tial1

Species
Rattus norvegicus
Symbol
Tial1
Name
Tia1 cytotoxic granule-associated RNA binding protein-like 1
Synonyms
  • MGC109552
  • nucleolysin TIAR
Biotype
protein coding gene
Automated Description
Predicted to enable mRNA 3'-UTR AU-rich region binding activity and protein-RNA adaptor activity. Predicted to be involved in negative regulation of cell population proliferation; positive regulation of hippo signaling; and positive regulation of miRNA-mediated gene silencing. Predicted to act upstream of or within germ cell development; positive regulation of stem cell proliferation; and stem cell division. Located in cytoplasmic stress granule. Part of ribonucleoprotein complex. Biomarker of transient cerebral ischemia. Orthologous to human TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1).
RGD Description
Predicted to enable mRNA 3'-UTR AU-rich region binding activity and protein-RNA adaptor activity. Predicted to be involved in negative regulation of cell population proliferation; positive regulation of hippo signaling; and positive regulation of miRNA-mediated gene silencing. Predicted to act upstream of or within germ cell development; positive regulation of stem cell proliferation; and stem cell division. Located in cytoplasmic stress granule. Part of ribonucleoprotein complex. Biomarker of transient cerebral ischemia. Orthologous to human TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10352
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Tial1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Tial1 role
            Tial1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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