Gene

Iqsec2

Species
Rattus norvegicus
Symbol
Iqsec2
Name
IQ motif and Sec7 domain ArfGEF 2
Synonyms
  • IQ motif and Sec7 domain 2
  • IQ motif and SEC7 domain-containing protein 2
Biotype
protein coding gene
Automated Description
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in modulation of chemical synaptic transmission; positive regulation of synapse assembly; and regulation of ARF protein signal transduction. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; photoreceptor ribbon synapse; and postsynaptic density. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 1. Orthologous to human IQSEC2 (IQ motif and Sec7 domain ArfGEF 2).
RGD Description
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in modulation of chemical synaptic transmission; positive regulation of synapse assembly; and regulation of ARF protein signal transduction. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; photoreceptor ribbon synapse; and postsynaptic density. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 1. Orthologous to human IQSEC2 (IQ motif and Sec7 domain ArfGEF 2); INTERACTS WITH 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil; bisphenol A.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10663
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
21.26M21.27M21.28M21.29M21.30M21.31M21.32M21.33M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions