Predicted to enable guanyl-nucleotide exchange factor activity. Involved in modulation of chemical synaptic transmission; positive regulation of synapse assembly; and regulation of ARF protein signal transduction. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; photoreceptor ribbon synapse; and postsynaptic density. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 1. Orthologous to human IQSEC2 (IQ motif and Sec7 domain ArfGEF 2).
RGD Description
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in modulation of chemical synaptic transmission; positive regulation of synapse assembly; and regulation of ARF protein signal transduction. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; photoreceptor ribbon synapse; and postsynaptic density. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 1. Orthologous to human IQSEC2 (IQ motif and Sec7 domain ArfGEF 2); INTERACTS WITH 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil; bisphenol A.