Version: 8.0.0
Date: Tue Jan 28 2025
Rnf220
Rattus norvegicusRGD:1598210
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Rnf220

Species
Rattus norvegicus
Symbol
Rnf220
Name
ring finger protein 220
Synonyms
  • E3 ubiquitin-protein ligase RNF220
  • hypothetical LOC500532
Biotype
protein coding gene
Automated Description
Predicted to enable beta-catenin binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway; protein autoubiquitination; and regulation of postsynaptic neurotransmitter receptor internalization. Predicted to act upstream of or within nervous system development; positive regulation of DNA-binding transcription factor activity; and protein monoubiquitination. Predicted to be located in cytoplasm and nuclear lamina. Predicted to be part of protein-containing complex. Predicted to be active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 23. Orthologous to human RNF220 (ring finger protein 220).
RGD Description
Predicted to enable beta-catenin binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway; protein autoubiquitination; and regulation of postsynaptic neurotransmitter receptor internalization. Predicted to act upstream of or within nervous system development; positive regulation of DNA-binding transcription factor activity; and protein monoubiquitination. Predicted to be located in cytoplasm and nuclear lamina. Predicted to be part of protein-containing complex. Predicted to be active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 23. Orthologous to human RNF220 (ring finger protein 220); INTERACTS WITH 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil; amitrole.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13459
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Rnf220 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Rnf220 role
            Rnf220 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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