Version: 8.1.0
Date: Fri Apr 18 2025
Aldh4a1
Rattus norvegicusRGD:1624206
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Aldh4a1

Species
Rattus norvegicus
Symbol
Aldh4a1
Name
aldehyde dehydrogenase 4 family, member A1
Synonyms
  • aldehyde dehydrogenase family 4 member A1
  • delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Biotype
protein coding gene
Automated Description
Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1).
RGD Description
Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14516
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Aldh4a1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
          Reference
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            Genetic Interactions

            Aldh4a1 role
            Aldh4a1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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