Version: 8.0.0
Date: Tue Jan 28 2025
A2m
Rattus norvegicusRGD:2004
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

A2m

Species
Rattus norvegicus
Symbol
A2m
Name
alpha-2-macroglobulin
Synonyms
  • A2m1
  • A2maa
Biotype
protein coding gene
Automated Description
Enables endopeptidase inhibitor activity; identical protein binding activity; and neurotrophin binding activity. Involved in several processes, including acute inflammatory response; embryonic liver development; and luteinization. Located in extracellular space. Used to study hemolytic anemia and toxic shock syndrome. Biomarker of several diseases, including liver disease (multiple); membranous glomerulonephritis; osteonecrosis; peritonitis; and trypanosomiasis. Human ortholog(s) of this gene implicated in COVID-19; background diabetic retinopathy; multiple sclerosis; neurodegenerative disease (multiple); and obstructive lung disease. Orthologous to human A2M (alpha-2-macroglobulin).
RGD Description
Enables endopeptidase inhibitor activity; identical protein binding activity; and neurotrophin binding activity. Involved in several processes, including acute inflammatory response; embryonic liver development; and luteinization. Located in extracellular space. Used to study hemolytic anemia and toxic shock syndrome. Biomarker of several diseases, including liver disease (multiple); membranous glomerulonephritis; osteonecrosis; peritonitis; and trypanosomiasis. Human ortholog(s) of this gene implicated in COVID-19; background diabetic retinopathy; multiple sclerosis; neurodegenerative disease (multiple); and obstructive lung disease. Orthologous to human A2M (alpha-2-macroglobulin); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; Alzheimer's disease pathway; immune response pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (S)-amphetamine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11412
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          A2m molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            A2m role
            A2m genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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