Gene

Adora2a

Species
Rattus norvegicus
Symbol
Adora2a
Name
adenosine A2a receptor
Synonyms
  • A2ar
  • ADENO
Biotype
protein coding gene
Automated Description
Enables G protein-coupled adenosine receptor activity; alpha-actinin binding activity; and type 5 metabotropic glutamate receptor binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; chemical synaptic transmission; and modulation of chemical synaptic transmission. Located in several cellular components, including axolemma; intermediate filament; and presynaptic active zone. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Used to study lung disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA2A (adenosine A2a receptor).
RGD Description
Enables G protein-coupled adenosine receptor activity; alpha-actinin binding activity; and type 5 metabotropic glutamate receptor binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; chemical synaptic transmission; and modulation of chemical synaptic transmission. Located in several cellular components, including axolemma; intermediate filament; and presynaptic active zone. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Used to study lung disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA2A (adenosine A2a receptor); PARTICIPATES IN adenosine signaling pathway; hypoxia inducible factor pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (S)-AMPA; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24246
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensADORA2A10 of 10YesYes  
Mus musculusAdora2a9 of 9YesYes   
Xenopus tropicalisadora2a9 of 9YesYes   
Danio rerioadora2aa9 of 9YesYes   
Drosophila melanogasterAdoR5 of 9YesYes   
Caenorhabditis elegansador-14 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Adora2b133076597 of 9 
Adora1230768517 of 9 
Adora3331561426 of 9 
Gpbar1434842232 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
BN-Adora2am1McwiRGD
BN-Adora2am2McwiRGD
BN-Adora2am3McwiRGD
SS-Adora2aem3McwiRGD
SS-Adora2aem5McwiRGD
Showing 1 - 5 of 5 rows
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Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
13.316M13.318M13.320M13.322M13.324M13.326M13.328M13.330M13.332M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions