Version: 8.0.0
Date: Tue Jan 28 2025
Adra2a
Rattus norvegicusRGD:2056
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Adra2a

Species
Rattus norvegicus
Symbol
Adra2a
Name
adrenoceptor alpha 2A
Synonyms
  • Adrenergic alpha 2A receptor
  • adrenergic receptor, alpha 2a
Biotype
protein coding gene
Automated Description
Enables alpha2-adrenergic receptor activity. Involved in several processes, including negative regulation of secretion by cell; negative regulation of uterine smooth muscle contraction; and response to morphine. Located in axon terminus and neuronal cell body. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Used to study anxiety disorder and depressive disorder. Biomarker of alcohol dependence; hypertension; morphine dependence; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; attention deficit hyperactivity disorder; familial partial lipodystrophy; nicotine dependence; and type 2 diabetes mellitus. Orthologous to human ADRA2A (adrenoceptor alpha 2A).
RGD Description
Enables alpha2-adrenergic receptor activity. Involved in several processes, including negative regulation of secretion by cell; negative regulation of uterine smooth muscle contraction; and response to morphine. Located in axon terminus and neuronal cell body. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Used to study anxiety disorder and depressive disorder. Biomarker of alcohol dependence; hypertension; morphine dependence; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; attention deficit hyperactivity disorder; familial partial lipodystrophy; nicotine dependence; and type 2 diabetes mellitus. Orthologous to human ADRA2A (adrenoceptor alpha 2A); INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; 2,3,4,7,8-Pentachlorodibenzofuran.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24248
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Must provide at least one subject
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            253.0605M253.0610M253.0615M253.0620M253.0625M253.0630M253.0635M253.0640M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Must provide at least one subject
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Adra2a molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Adra2a role
              Adra2a genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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