Version: 8.1.0
Date: Fri Apr 18 2025
Grk3
Rattus norvegicusRGD:2063
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Grk3

Species
Rattus norvegicus
Symbol
Grk3
Name
G protein-coupled receptor kinase 3
Synonyms
  • Adrbk2
  • Adrenergic receptor kinase beta 2 (G-protein-linked receptor kinase)
Biotype
protein coding gene
Automated Description
Enables D1 dopamine receptor binding activity; G protein-coupled receptor kinase activity; and beta-adrenergic receptor kinase activity. Involved in several processes, including desensitization of G protein-coupled receptor signaling pathway; inositol phosphate metabolic process; and rhodopsin metabolic process. Located in several cellular components, including Z disc; dendrite; and sperm midpiece. Is active in glutamatergic synapse; postsynaptic density; and presynapse. Biomarker of Parkinson's disease; hypertension; and hypothyroidism. Orthologous to human GRK3 (G protein-coupled receptor kinase 3).
RGD Description
Enables D1 dopamine receptor binding activity; G protein-coupled receptor kinase activity; and beta-adrenergic receptor kinase activity. Involved in several processes, including desensitization of G protein-coupled receptor signaling pathway; inositol phosphate metabolic process; and rhodopsin metabolic process. Located in several cellular components, including Z disc; dendrite; and sperm midpiece. Is active in glutamatergic synapse; postsynaptic density; and presynapse. Biomarker of Parkinson's disease; hypertension; and hypothyroidism. Orthologous to human GRK3 (G protein-coupled receptor kinase 3); PARTICIPATES IN G protein mediated signaling pathway; angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24355
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensGRK310 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Mus musculusGrk39 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalisgrk39 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Drosophila melanogasterGprk19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Caenorhabditis elegansgrk-29 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Grk2168692818 of 9☑☐☑☑☑☑☑☑☑ 
Grk5259450354 of 9☑☐☑☐☐☐☑☑☐ 
Grk6353955384 of 9☑☐☑☐☐☐☑☑☐ 
Grk4455753354 of 9☑☐☑☐☐☐☑☑☐ 
Grk1554254344 of 9☑☐☑☐☐☐☑☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
No data available

Alleles and Variants

Genome location
Assembly version
mRatBN7.2
Viewer Help
Data currently unavailable; sequence viewer under construction
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_051347.1:g.43639716G>Avariant
SNP
  • intron variant
NC_051347.1:g.43644673T>Gvariant
SNP
  • intron variant
NC_051347.1:g.43646809G>Cvariant
SNP
  • intron variant
NC_051347.1:g.43637658T>Cvariant
SNP
  • intron variant
NC_051347.1:g.43638333C>Tvariant
SNP
  • intron variant
NC_051347.1:g.43638709A>Gvariant
SNP
  • intron variant
NC_051347.1:g.43666143A>Cvariant
SNP
  • intron variant
NC_051347.1:g.43666264A>Gvariant
SNP
  • intron variant
NC_051347.1:g.43650992C>Tvariant
SNP
  • intron variant
NC_051347.1:g.43694212A>Gvariant
SNP
  • intron variant
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View detailed Alleles/Variants information
Download all Alleles/Variants for all genes of the species

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available