Species

Rattus norvegicus

Symbol

Ak1

Name

adenylate kinase 1

Synonyms

adenylate kinase isoenzyme 1
adenylate kinase isoenzyme 1-like

Biotype

protein coding gene

Automated Description

Enables adenylate kinase activity. Contributes to phosphotransferase activity, phosphate group as acceptor. Involved in several processes, including nervous system development; nucleobase-containing small molecule metabolic process; and positive regulation of neuron maturation. Located in perinuclear region of cytoplasm and sarcomere. Biomarker of middle cerebral artery infarction; myocardial infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1).

RGD Description

Enables adenylate kinase activity. Contributes to phosphotransferase activity, phosphate group as acceptor. Involved in several processes, including inosine biosynthetic process; nervous system development; and purine ribonucleotide metabolic process. Located in perinuclear region of cytoplasm and sarcomere. Biomarker of middle cerebral artery infarction; myocardial infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1); PARTICIPATES IN adefovir pharmacokinetics pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; INTERACTS WITH (S)-colchicine; 1-naphthyl isothiocyanate; 3-chloropropane-1,2-diol.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR23359

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

Cell color indicative of annotation volume

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Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

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Sequence Feature Viewer

Genome location

Chr3:15912431...15923045 + (10.61 kb)

Assembly version

mRatBN7.2

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Ak1 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
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Genetic Interactions

Ak1 role	Ak1 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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