Gene

Apex1

Species
Rattus norvegicus
Symbol
Apex1
Name
apurinic/apyrimidinic endodeoxyribonuclease 1
Synonyms
  • AP endonuclease 1
  • APE
Biotype
protein coding gene
Automated Description
Enables NF-kappaB binding activity and RNA endonuclease activity. Involved in several processes, including cellular response to Thyroid stimulating hormone; cellular response to cAMP; and positive regulation of G1/S transition of mitotic cell cycle. Part of transcription regulator complex. Biomarker of brain ischemia; hepatocellular carcinoma; lung disease; and status epilepticus. Human ortholog(s) of this gene implicated in artery disease (multiple); breast cancer; female reproductive organ cancer (multiple); spina bifida; and urinary bladder cancer. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1).
RGD Description
Enables NF-kappaB binding activity and RNA endonuclease activity. Involved in several processes, including cellular response to Thyroid stimulating hormone; cellular response to cAMP; and positive regulation of G1/S transition of mitotic cell cycle. Part of transcription regulator complex. Biomarker of brain ischemia; hepatocellular carcinoma; lung disease; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in artery disease (multiple); breast cancer; female reproductive organ cancer (multiple); spina bifida; and urinary bladder cancer. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1); PARTICIPATES IN base excision repair pathway; hypoxia inducible factor pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 1,2,4-trimethylbenzene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22748
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
24.1444M24.1446M24.1448M24.1450M24.1452M24.1454M24.1456M24.1458M24.1460M24.1462M24.1464M24.1466M

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions