Enables NF-kappaB binding activity and RNA endonuclease activity. Involved in several processes, including cellular response to Thyroid stimulating hormone; cellular response to cAMP; and positive regulation of G1/S transition of mitotic cell cycle. Part of transcription regulator complex. Biomarker of brain ischemia; hepatocellular carcinoma; lung disease; and status epilepticus. Human ortholog(s) of this gene implicated in artery disease (multiple); breast cancer; female reproductive organ cancer (multiple); spina bifida; and urinary bladder cancer. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1).
RGD Description
Enables NF-kappaB binding activity and RNA endonuclease activity. Involved in several processes, including cellular response to Thyroid stimulating hormone; cellular response to cAMP; and positive regulation of G1/S transition of mitotic cell cycle. Part of transcription regulator complex. Biomarker of brain ischemia; hepatocellular carcinoma; lung disease; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in artery disease (multiple); breast cancer; female reproductive organ cancer (multiple); spina bifida; and urinary bladder cancer. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1); PARTICIPATES IN base excision repair pathway; hypoxia inducible factor pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 1,2,4-trimethylbenzene.