Version: 8.0.0
Date: Tue Jan 28 2025
Apoa1
Rattus norvegicusRGD:2130
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Apoa1

Species
Rattus norvegicus
Symbol
Apoa1
Name
apolipoprotein A1
Synonyms
  • apo-AI
  • apoA-I
Biotype
protein coding gene
Automated Description
Enables amyloid-beta binding activity; cholesterol transfer activity; and lipase inhibitor activity. Involved in several processes, including negative regulation of lipase activity; peripheral nervous system axon regeneration; and response to estrogen. Located in cell surface and extracellular space. Part of discoidal high-density lipoprotein particle; intermediate-density lipoprotein particle; and low-density lipoprotein particle. Used to study arteriosclerosis and hyperthyroidism. Biomarker of several diseases, including artery disease (multiple); major depressive disorder; ocular hypertension; sciatic neuropathy; and steatotic liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial hypercholesterolemia; hypolipoproteinemia (multiple); metabolic dysfunction-associated steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1).
RGD Description
Enables amyloid-beta binding activity; cholesterol transfer activity; and lipase inhibitor activity. Involved in several processes, including negative regulation of lipase activity; peripheral nervous system axon regeneration; and response to estrogen. Located in cell surface and extracellular space. Part of discoidal high-density lipoprotein particle; intermediate-density lipoprotein particle; and low-density lipoprotein particle. Used to study arteriosclerosis and hyperthyroidism. Biomarker of several diseases, including hypertension; major depressive disorder; ocular hypertension; sciatic neuropathy; and steatotic liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial hypercholesterolemia; hypolipoproteinemia (multiple); metabolic dysfunction-associated steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1); PARTICIPATES IN altered lipoprotein metabolic pathway; forkhead class A signaling pathway; lipoprotein metabolic pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 1-naphthyl isothiocyanate; 2,2,2-tetramine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR18976
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Apoa1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Apoa1 role
            Apoa1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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