Version: 8.0.0
Date: Tue Jan 28 2025
Bdkrb2
Rattus norvegicusRGD:2201
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Bdkrb2

Species
Rattus norvegicus
Symbol
Bdkrb2
Name
bradykinin receptor B2
Synonyms
  • B2 bradykinin receptor
  • B2BKR
Biotype
protein coding gene
Automated Description
Enables beta-2 adrenergic receptor binding activity and bradykinin receptor activity. Involved in several processes, including acute inflammatory response to antigenic stimulus; cellular response to hypoxia; and maintenance of blood-brain barrier. Predicted to be located in Golgi apparatus and endosome. Predicted to be active in plasma membrane. Used to study several diseases, including asthma; pancreatitis; pleurisy; portal hypertension; and pulmonary hypertension. Biomarker of high grade glioma; hypertension; myocardial infarction; and sciatic neuropathy. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; hypertension; and rhinitis. Orthologous to human BDKRB2 (bradykinin receptor B2).
RGD Description
Enables beta-2 adrenergic receptor binding activity and bradykinin receptor activity. Involved in several processes, including acute inflammatory response to antigenic stimulus; cellular response to hypoxia; and maintenance of blood-brain barrier. Predicted to be located in Golgi apparatus and endosome. Predicted to be active in plasma membrane. Used to study several diseases, including asthma; pancreatitis; pleurisy; portal hypertension; and pulmonary hypertension. Biomarker of high grade glioma; hypertension; myocardial infarction; and sciatic neuropathy. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; hypertension; and rhinitis. Orthologous to human BDKRB2 (bradykinin receptor B2); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; kallikrein-kinin cascade pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic GMP; 4-amino-2,6-dinitrotoluene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10489
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Bdkrb2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Bdkrb2 role
            Bdkrb2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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