Gene

Camk2a

Species
Rattus norvegicus
Symbol
Camk2a
Name
calcium/calmodulin-dependent protein kinase II alpha
Synonyms
  • alpha CaM kinase II
  • Ca2+/calmodulin-dependent protein kinase II alpha
Biotype
protein coding gene
Automated Description
Enables GTPase activating protein binding activity and calcium/calmodulin-dependent protein kinase activity. Involved in several processes, including neurotransmitter receptor transport to plasma membrane; protein phosphorylation; and regulation of protein localization to cell periphery. Located in axon; dendrite cytoplasm; and neuronal cell body. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density; and presynaptic cytosol. Biomarker of middle cerebral artery infarction and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 53 and autosomal recessive intellectual developmental disorder 63. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha).
RGD Description
Enables GTPase activating protein binding activity and calcium/calmodulin-dependent protein kinase activity. Involved in several processes, including neurotransmitter receptor transport to plasma membrane; protein phosphorylation; and regulation of protein localization to cell periphery. Located in axon; dendrite cytoplasm; and neuronal cell body. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density; and presynaptic cytosol. Biomarker of middle cerebral artery infarction and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 53 and autosomal recessive intellectual developmental disorder 63. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; fibroblast growth factor signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24347
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
54.38M54.39M54.40M54.41M54.42M54.43M54.44M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions