calcium/calmodulin-dependent protein kinase II alpha
Synonyms
alpha CaM kinase II
Ca2+/calmodulin-dependent protein kinase II alpha
Biotype
protein coding gene
Automated Description
Enables GTPase activating protein binding activity and calcium/calmodulin-dependent protein kinase activity. Involved in several processes, including neurotransmitter receptor transport to plasma membrane; protein phosphorylation; and regulation of protein localization to cell periphery. Located in axon; dendrite cytoplasm; and neuronal cell body. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density; and presynaptic cytosol. Biomarker of middle cerebral artery infarction and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 53 and autosomal recessive intellectual developmental disorder 63. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha).
RGD Description
Enables GTPase activating protein binding activity and calcium/calmodulin-dependent protein kinase activity. Involved in several processes, including neurotransmitter receptor transport to plasma membrane; protein phosphorylation; and regulation of protein localization to cell periphery. Located in axon; dendrite cytoplasm; and neuronal cell body. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density; and presynaptic cytosol. Biomarker of middle cerebral artery infarction and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 53 and autosomal recessive intellectual developmental disorder 63. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; fibroblast growth factor signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile.