Gene

Capn2

Species
Rattus norvegicus
Symbol
Capn2
Name
calpain 2
Synonyms
  • calcium-activated neutral proteinase 2
  • calpain 2, (m/II) large subunit
Biotype
protein coding gene
Automated Description
Enables calcium ion binding activity; cytoskeletal protein binding activity; and enzyme binding activity. Contributes to calcium-dependent cysteine-type endopeptidase activity. Involved in several processes, including cellular response to interferon-beta; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of myoblast fusion. Located in several cellular components, including external side of plasma membrane; focal adhesion; and neuronal cell body. Biomarker of hypertrophic cardiomyopathy; sciatic neuropathy; and traumatic brain injury. Orthologous to human CAPN2 (calpain 2).
RGD Description
Enables calcium ion binding activity; cytoskeletal protein binding activity; and enzyme binding activity. Contributes to calcium-dependent cysteine-type endopeptidase activity. Involved in several processes, including cellular response to interferon-beta; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of myoblast fusion. Located in several cellular components, including external side of plasma membrane; focal adhesion; and neuronal cell body. Biomarker of hypertrophic cardiomyopathy; sciatic neuropathy; and traumatic brain injury. Orthologous to human CAPN2 (calpain 2); PARTICIPATES IN the proteolytic pathway involving calcium-dependent proteases; Alzheimer's disease pathway; apoptotic cell death pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10183
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
94.155M94.160M94.165M94.170M94.175M94.180M94.185M94.190M94.195M94.200M

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions