Predicted to enable several functions, including S-adenosyl-L-methionine binding activity; carbon monoxide binding activity; and cystathionine beta-synthase activity. Involved in several processes, including cellular response to hypoxia; hydrogen sulfide biosynthetic process; and transsulfuration. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Biomarker of hyperhomocysteinemia and vitamin B12 deficiency. Human ortholog(s) of this gene implicated in several diseases, including cerebral infarction; homocystinuria; hyperhomocysteinemia; malaria; and neural tube defect. Orthologous to human CBS (cystathionine beta-synthase).
RGD Description
Predicted to enable several functions, including S-adenosyl-L-methionine binding activity; carbon monoxide binding activity; and cystathionine beta-synthase activity. Involved in several processes, including cellular response to hypoxia; hydrogen sulfide biosynthetic process; and transsulfuration. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Biomarker of hyperhomocysteinemia and vitamin B12 deficiency. Human ortholog(s) of this gene implicated in several diseases, including cerebral infarction; homocystinuria; hyperhomocysteinemia; malaria; and neural tube defect. Orthologous to human CBS (cystathionine beta-synthase); PARTICIPATES IN cystathioninuria pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.