Gene

Ormdl1

Species
Rattus norvegicus
Symbol
Ormdl1
Name
ORMDL sphingolipid biosynthesis regulator 1
Synonyms
  • hypothetical protein LOC100188936
  • MGC188592
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including RNA-DNA hybrid ribonuclease activity; RNA-directed DNA polymerase activity; and zinc ion binding activity. Predicted to be involved in ceramide metabolic process; intracellular sphingolipid homeostasis; and sphingolipid biosynthetic process. Predicted to act upstream of or within negative regulation of ceramide biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of serine palmitoyltransferase complex. Orthologous to human ORMDL1 (ORMDL sphingolipid biosynthesis regulator 1).
RGD Description
Predicted to enable several functions, including RNA-DNA hybrid ribonuclease activity; RNA-directed DNA polymerase activity; and zinc ion binding activity. Predicted to be involved in ceramide metabolic process; intracellular sphingolipid homeostasis; and sphingolipid biosynthetic process. Predicted to act upstream of or within negative regulation of ceramide biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of serine palmitoyltransferase complex. Orthologous to human ORMDL1 (ORMDL sphingolipid biosynthesis regulator 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; endosulfan.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR41694
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
48.238M48.240M48.242M48.244M48.246M48.248M48.250M48.252M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions