Version: 8.0.0Date: Tue Jan 28 2025
Gene
Gigyf2
- Species
- Rattus norvegicus
- Symbol
- Gigyf2
- Name
- GRB10 interacting GYF protein 2
- Synonyms
- GRB10-interacting GYF protein 2
- LOC100362458
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable molecular adaptor activity and proline-rich region binding activity. Predicted to be involved in several processes, including insulin-like growth factor receptor signaling pathway; negative regulation of type I interferon-mediated signaling pathway; and post-transcriptional regulation of gene expression. Predicted to act upstream of or within several processes, including adult locomotory behavior; mitotic G1 DNA damage checkpoint signaling; and spinal cord motor neuron differentiation. Predicted to be located in several cellular components, including Golgi apparatus; cytoplasmic stress granule; and endosome. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including cytosol; perikaryon; and proximal dendrite. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GIGYF2 (GRB10 interacting GYF protein 2).
- RGD Description
- Predicted to enable molecular adaptor activity and proline-rich region binding activity. Predicted to be involved in negative regulation of type I interferon-mediated signaling pathway; post-transcriptional regulation of gene expression; and rescue of stalled ribosome. Predicted to act upstream of or within several processes, including insulin-like growth factor receptor signaling pathway; mitotic G1 DNA damage checkpoint signaling; and spinal cord motor neuron differentiation. Predicted to be located in several cellular components, including cytoplasmic stress granule; perikaryon; and proximal dendrite. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GIGYF2 (GRB10 interacting GYF protein 2); INTERACTS WITH 17beta-estradiol; bisphenol A; Cuprizon.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR14445
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr9:88001212...88127040 + (125.83 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.