Version: 8.1.0
Date: Fri Apr 18 2025
Cdkn2a
Rattus norvegicusRGD:2323
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Cdkn2a

Species
Rattus norvegicus
Symbol
Cdkn2a
Name
cyclin-dependent kinase inhibitor 2A
Synonyms
  • alternative reading frame
  • Arf
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; MDM2/MDM4 family protein binding activity; and enzyme inhibitor activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of hepatocyte proliferation; and nervous system development. Predicted to be located in mitochondrion; nuclear lumen; and senescence-associated heterochromatin focus. Predicted to be part of protein-containing complex. Used to study carcinoma (multiple); endometrial cancer; pre-malignant neoplasm; rhabdomyosarcoma; and sarcomatoid mesothelioma. Biomarker of hepatocellular carcinoma; hypertension; obesity; and osteoarthritis. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); melanoma (multiple); and pancreatic cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A).
RGD Description
Predicted to enable several functions, including MDM2/MDM4 family protein binding activity; NF-kappaB binding activity; and enzyme inhibitor activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of hepatocyte proliferation; and nervous system development. Predicted to be located in mitochondrion; nuclear lumen; and senescence-associated heterochromatin focus. Predicted to be part of protein-containing complex. Used to study carcinoma (multiple); endometrial cancer; pre-malignant neoplasm; rhabdomyosarcoma; and sarcomatoid mesothelioma. Biomarker of hepatocellular carcinoma; hypertension; obesity; and osteoarthritis. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); melanoma (multiple); and pancreatic cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A); PARTICIPATES IN altered G1/S transition pathway; G1/S transition pathway; pancreatic cancer pathway; INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24201
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Cdkn2a molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
          Reference
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            Genetic Interactions

            Cdkn2a role
            Cdkn2a genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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