Version: 8.1.0Date: Fri Apr 18 2025
Gene
Cebpa
- Species
- Rattus norvegicus
- Symbol
- Cebpa
- Name
- CCAAT/enhancer binding protein alpha
- Synonyms
- C/EBP alpha
- CAAT/enhancer-binding protein DNA-binding protein
- Biotype
- protein coding gene
- Automated Description
- Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and protein dimerization activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including osteoblast development; positive regulation of fat cell differentiation; and regulation of transcription by RNA polymerase II. Located in nuclear matrix and nucleolus. Part of CHOP-C/EBP complex and Rb-E2F complex. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human CEBPA (CCAAT enhancer binding protein alpha).
- RGD Description
- Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and protein dimerization activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including osteoblast development; positive regulation of fat cell differentiation; and regulation of transcription by RNA polymerase II. Located in nuclear matrix and nucleolus. Part of CHOP-C/EBP complex and Rb-E2F complex. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human CEBPA (CCAAT enhancer binding protein alpha); PARTICIPATES IN forkhead class A signaling pathway; acute myeloid leukemia pathway; INTERACTS WITH (+)-pilocarpine; (-)-cotinine; (S)-nicotine.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR23334
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr1:87759433...87762412 + (2.98 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.