Version: 8.1.0
Date: Fri Apr 18 2025
Dyrk1a
Rattus norvegicusRGD:2528
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Dyrk1a

Species
Rattus norvegicus
Symbol
Dyrk1a
Name
dual specificity tyrosine phosphorylation regulated kinase 1A
Synonyms
  • dual specificity tyrosine-phosphorylation-regulated kinase 1A
  • Dual Specificity Yak1-related kinase
Biotype
protein coding gene
Automated Description
Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in several processes, including protein phosphorylation; regulation of RNA splicing; and regulation of cardiac muscle tissue growth. Located in nuclear speck. Used to study congestive heart failure and dilated cardiomyopathy. Biomarker of hyperhomocysteinemia; myocardial infarction; and renovascular hypertension. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant intellectual developmental disorder 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A).
RGD Description
Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in several processes, including protein phosphorylation; regulation of RNA splicing; and regulation of cardiac muscle tissue growth. Located in nuclear speck. Used to study congestive heart failure and dilated cardiomyopathy. Biomarker of hyperhomocysteinemia; myocardial infarction; and renovascular hypertension. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant intellectual developmental disorder 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A); INTERACTS WITH (-)-epigallocatechin 3-gallate; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24058
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Dyrk1a molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
          Reference
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            Genetic Interactions

            Dyrk1a role
            Dyrk1a genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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