Version: 8.1.0Date: Fri Apr 18 2025
Gene
Edn1
- Species
- Rattus norvegicus
- Symbol
- Edn1
- Name
- endothelin 1
- Synonyms
- endothelin-1
- ET-1
- Biotype
- protein coding gene
- Automated Description
- Enables endothelin A receptor binding activity and endothelin B receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; regulation of secretion by cell; and response to corticosteroid. Located in several cellular components, including Weibel-Palade body; basal part of cell; and rough endoplasmic reticulum lumen. Used to study adult respiratory distress syndrome; coronary artery disease; membranoproliferative glomerulonephritis; metabolic acidosis; and portal hypertension. Biomarker of several diseases, including artery disease (multiple); heart disease (multiple); kidney failure (multiple); lung disease (multiple); and nephritis (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bronchial disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1).
- RGD Description
- Enables endothelin A receptor binding activity and endothelin B receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; regulation of secretion by cell; and response to corticosteroid. Located in several cellular components, including Weibel-Palade body; basal part of cell; and rough endoplasmic reticulum lumen. Used to study adult respiratory distress syndrome; coronary artery disease; membranoproliferative glomerulonephritis; metabolic acidosis; and portal hypertension. Biomarker of several diseases, including artery disease (multiple); heart disease (multiple); kidney failure (multiple); lung disease (multiple); and nephritis (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bronchial disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1); PARTICIPATES IN inflammatory response pathway; endothelin signaling pathway; hypoxia inducible factor pathway; INTERACTS WITH (+)-catechin; (R)-noradrenaline; 1,3-dinitrobenzene.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR13874
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr17:22454420...22460885 - (6.47 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.