Version: 8.1.0
Date: Fri Apr 18 2025
Fgf10
Rattus norvegicusRGD:2606
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Fgf10

Species
Rattus norvegicus
Symbol
Fgf10
Name
fibroblast growth factor 10
Synonyms
  • FGF-10
  • Fgf5a
Biotype
protein coding gene
Automated Description
Predicted to enable heparin binding activity; receptor ligand activity; and type 2 fibroblast growth factor receptor binding activity. Involved in several processes, including angiogenesis; response to estradiol; and response to lipopolysaccharide. Acts upstream of or within organ induction. Predicted to be located in several cellular components, including cell surface; collagen-containing extracellular matrix; and nucleus. Predicted to be active in cytoplasm and extracellular space. Biomarker of hypospadias. Human ortholog(s) of this gene implicated in aplasia of lacrimal and salivary glands and lacrimoauriculodentodigital syndrome 3. Orthologous to human FGF10 (fibroblast growth factor 10).
RGD Description
Predicted to enable heparin binding activity; receptor ligand activity; and type 2 fibroblast growth factor receptor binding activity. Involved in several processes, including angiogenesis; response to estradiol; and response to lipopolysaccharide. Acts upstream of or within organ induction. Predicted to be located in several cellular components, including cell surface; collagen-containing extracellular matrix; and nucleus. Predicted to be active in cytoplasm and extracellular space. Biomarker of hypospadias. Human ortholog(s) of this gene implicated in aplasia of lacrimal and salivary glands and lacrimoauriculodentodigital syndrome 3. Orthologous to human FGF10 (fibroblast growth factor 10); PARTICIPATES IN melanoma pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17beta-estradiol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11486
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Fgf10 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
          Reference
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            Genetic Interactions

            Fgf10 role
            Fgf10 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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