Gene

Gabrb1

Species
Rattus norvegicus
Symbol
Gabrb1
Name
gamma-aminobutyric acid type A receptor subunit beta1
Synonyms
  • GABA(A) receptor subunit beta-1
  • GABAAR subunit beta-1
Biotype
protein coding gene
Automated Description
Enables GABA receptor binding activity; GABA-A receptor activity; and monoatomic ion channel activity. Involved in several processes, including cellular response to histamine; central nervous system neuron development; and response to progesterone. Located in dendrite; nuclear envelope; and plasma membrane. Part of GABA-A receptor complex. Is active in GABA-ergic synapse; postsynaptic specialization membrane; and presynaptic active zone membrane. Biomarker of hepatic encephalopathy. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 45. Orthologous to human GABRB1 (gamma-aminobutyric acid type A receptor subunit beta1).
RGD Description
Enables GABA receptor binding activity; GABA-A receptor activity; and monoatomic ion channel activity. Involved in several processes, including cellular response to histamine; central nervous system neuron development; and response to progesterone. Located in dendrite; nuclear envelope; and plasma membrane. Part of GABA-A receptor complex. Is active in GABA-ergic synapse; postsynaptic specialization membrane; and presynaptic active zone membrane. Biomarker of hepatic encephalopathy. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 45. Orthologous to human GABRB1 (gamma-aminobutyric acid type A receptor subunit beta1); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR18945
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
36.10M36.15M36.20M36.25M36.30M36.35M36.40M36.45M36.50M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions