Version: 8.1.0
Date: Fri Apr 18 2025
Gck
Rattus norvegicusRGD:2670
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Gck

Species
Rattus norvegicus
Symbol
Gck
Name
glucokinase
Synonyms
  • GLK
  • glucokinase variant 3
Biotype
protein coding gene
Automated Description
Enables several functions, including D-glucose binding activity; adenyl ribonucleotide binding activity; and hexokinase activity. Involved in several processes, including hexose metabolic process; positive regulation of phosphate metabolic process; and regulation of secretion by cell. Located in several cellular components, including actin filament; basal cortex; and secretory granule. Used to study obesity; steatotic liver disease; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in artery disease (multiple) and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase).
RGD Description
Enables several functions, including D-glucose binding activity; adenyl ribonucleotide binding activity; and hexokinase activity. Involved in several processes, including hexose metabolic process; positive regulation of phosphate metabolic process; and regulation of secretion by cell. Located in several cellular components, including actin filament; basal cortex; and secretory granule. Used to study obesity; steatotic liver disease; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in artery disease (multiple) and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase); PARTICIPATES IN glycogen biosynthetic pathway; glycogen metabolic pathway; glycolysis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19443
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Gck molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
          Reference
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            Genetic Interactions

            Gck role
            Gck genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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