Version: 8.1.0
Date: Fri Apr 18 2025
Gnai1
Rattus norvegicusRGD:2713
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Gnai1

Species
Rattus norvegicus
Symbol
Gnai1
Name
G protein subunit alpha i1
Synonyms
  • adenylate cyclase-inhibiting G alpha protein
  • BPGTPB
Biotype
protein coding gene
Automated Description
Enables several functions, including GTPase activating protein binding activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Involved in several processes, including cellular response to forskolin; negative regulation of synaptic transmission; and neurotransmitter receptor localization to postsynaptic specialization membrane. Located in centrosome; cytoplasm; and plasma membrane. Part of protein-containing complex. Is active in glutamatergic synapse and postsynapse. Orthologous to human GNAI1 (G protein subunit alpha i1).
RGD Description
Enables several functions, including GTPase activating protein binding activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Involved in several processes, including cellular response to forskolin; negative regulation of synaptic transmission; and neurotransmitter receptor localization to postsynaptic specialization membrane. Located in centrosome; cytoplasm; and plasma membrane. Part of protein-containing complex. Is active in glutamatergic synapse and postsynapse. Orthologous to human GNAI1 (G protein subunit alpha i1); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2-methoxyethanol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10218
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Alleles and Variants

Download all Alleles/Variants for all genes of the species

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions