Version: 8.0.0
Date: Tue Jan 28 2025
Gnas
Rattus norvegicusRGD:2716
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Gnas

Species
Rattus norvegicus
Symbol
Gnas
Name
GNAS complex locus
Synonyms
  • adenylate cyclase-stimulating G alpha protein
  • ALEX
Biotype
protein coding gene
Automated Description
Enables several functions, including G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and signaling receptor binding activity. Involved in several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; cellular response to prostaglandin E stimulus; and regulation of primary metabolic process. Located in several cellular components, including cytoplasmic vesicle; ruffle; and sarcolemma. Part of heterotrimeric G-protein complex. Biomarker of polycystic kidney disease. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; obesity; pituitary adenoma 3; progressive osseous heteroplasia; and pseudohypoparathyroidism (multiple). Orthologous to human GNAS (GNAS complex locus).
RGD Description
Enables several functions, including G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and signaling receptor binding activity. Involved in several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; cellular response to prostaglandin E stimulus; and positive regulation of sodium ion transport. Located in several cellular components, including cytoplasmic vesicle; ruffle; and sarcolemma. Part of heterotrimeric G-protein complex. Biomarker of polycystic kidney disease. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; obesity; pituitary adenoma 3; progressive osseous heteroplasia; and pseudohypoparathyroidism (multiple). Orthologous to human GNAS (GNAS complex locus); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; vasopressin signaling pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10218
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Download all Alleles/Variants for all genes of the species

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            163.08M163.09M163.10M163.11M163.12M163.13M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Gnas molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Gnas role
              Gnas genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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