Version: 8.0.0
Date: Tue Jan 28 2025
Gnb1
Rattus norvegicusRGD:2718
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Gnb1

Species
Rattus norvegicus
Symbol
Gnb1
Name
G protein subunit beta 1
Synonyms
  • guanine nucleotide binding protein (G protein), beta 1
  • guanine nucleotide binding protein (G protein), beta polypeptide 1
Biotype
protein coding gene
Automated Description
Enables alkylglycerophosphoethanolamine phosphodiesterase activity and spectrin binding activity. Involved in G protein-coupled receptor signaling pathway and positive regulation of cytosolic calcium ion concentration. Acts upstream of or within cardiac muscle cell apoptotic process and cellular response to hypoxia. Located in several cellular components, including cell body; photoreceptor inner segment; and photoreceptor outer segment membrane. Part of heterotrimeric G-protein complex. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; autosomal dominant intellectual developmental disorder 42; congestive heart failure; and myelodysplastic syndrome. Orthologous to human GNB1 (G protein subunit beta 1).
RGD Description
Enables alkylglycerophosphoethanolamine phosphodiesterase activity and spectrin binding activity. Involved in G protein-coupled receptor signaling pathway and positive regulation of cytosolic calcium ion concentration. Acts upstream of or within cardiac muscle cell apoptotic process and cellular response to hypoxia. Located in several cellular components, including cell body; photoreceptor inner segment; and photoreceptor outer segment membrane. Part of heterotrimeric G-protein complex. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; autosomal dominant intellectual developmental disorder 42; congestive heart failure; and myelodysplastic syndrome. Orthologous to human GNB1 (G protein subunit beta 1); PARTICIPATES IN G protein mediated signaling pathway via Galpha12/Galpha13 family; adenosine signaling pathway; dopamine signaling pathway via D1 family of receptors; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19850
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            166.08M166.09M166.10M166.11M166.12M166.13M166.14M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Gnb1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Gnb1 role
              Gnb1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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