Species

Rattus norvegicus

Symbol

Grik1

Name

glutamate ionotropic receptor kainate type subunit 1

Synonyms

GluK1
GluR-5

Biotype

protein coding gene

Automated Description

Enables several functions, including glutamate binding activity; ligand-gated monoatomic ion channel activity; and scaffold protein binding activity. Contributes to heterocyclic compound binding activity. Involved in ionotropic glutamate receptor signaling pathway; modulation of chemical synaptic transmission; and nervous system development. Located in dendrite; neuronal cell body; and terminal bouton. Part of ionotropic glutamate receptor complex. Is active in glutamatergic synapse and presynaptic membrane. Used to study status epilepticus. Human ortholog(s) of this gene implicated in childhood absence epilepsy. Orthologous to human GRIK1 (glutamate ionotropic receptor kainate type subunit 1).

RGD Description

Enables several functions, including glutamate binding activity; ligand-gated monoatomic ion channel activity; and scaffold protein binding activity. Contributes to heterocyclic compound binding activity. Involved in ionotropic glutamate receptor signaling pathway; modulation of chemical synaptic transmission; and nervous system development. Located in dendrite; neuronal cell body; and terminal bouton. Part of ionotropic glutamate receptor complex. Is active in glutamatergic synapse and presynaptic membrane. Used to study status epilepticus. Human ortholog(s) of this gene implicated in childhood absence epilepsy. Orthologous to human GRIK1 (glutamate ionotropic receptor kainate type subunit 1); PARTICIPATES IN long term potentiation; glutamate signaling pathway; INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 6-propyl-2-thiouracil.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR18966

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

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Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

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Sequence Feature Viewer

Genome location

Chr11:27169739...27571131 - (401.39 kb)

Assembly version

mRatBN7.2

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Grik1 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection method	Source	Reference
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Genetic Interactions

Grik1 role	Grik1 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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