Version: 8.0.0
Date: Tue Jan 28 2025
Gusb
Rattus norvegicusRGD:2772
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Gusb

Species
Rattus norvegicus
Symbol
Gusb
Name
glucuronidase, beta
Synonyms
  • Ac2-223
  • beta-glucuronidase
Biotype
protein coding gene
Automated Description
Enables beta-glucuronidase activity and carbohydrate binding activity. Predicted to be involved in chondroitin sulfate catabolic process; heparan sulfate proteoglycan catabolic process; and hyaluronan catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular space and lysosomal lumen. Biomarker of mucopolysaccharidosis and peritonitis. Human ortholog(s) of this gene implicated in Sly syndrome. Orthologous to human GUSB (glucuronidase beta).
RGD Description
Enables beta-glucuronidase activity and carbohydrate binding activity. Predicted to be involved in chondroitin sulfate catabolic process; heparan sulfate proteoglycan catabolic process; and hyaluronan catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular space and lysosomal lumen. Biomarker of mucopolysaccharidosis and peritonitis. Human ortholog(s) of this gene implicated in Sly syndrome. Orthologous to human GUSB (glucuronidase beta); PARTICIPATES IN acute intermittent porphyria pathway; congenital sucrase-isomaltase deficiency pathway; erythropoietic porphyria pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (R)-lipoic acid.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10066
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Gusb molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Gusb role
            Gusb genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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