Gene

Hras

Species
Rattus norvegicus
Symbol
Hras
Name
HRas proto-oncogene, GTPase
Synonyms
  • c-H-ras
  • GTPase HRas
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including GTPase activity; guanyl ribonucleotide binding activity; and phospholipase C activator activity. Involved in several processes, including Ras protein signal transduction; positive regulation of DNA replication; and positive regulation of ERK1 and ERK2 cascade. Acts upstream of or within positive regulation of Ras protein signal transduction. Located in plasma membrane. Used to study diabetic retinopathy and liver carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase).
RGD Description
Predicted to enable several functions, including GTPase activity; guanyl ribonucleotide binding activity; and phospholipase C activator activity. Involved in several processes, including Ras protein signal transduction; cellular senescence; and positive regulation of ERK1 and ERK2 cascade. Acts upstream of or within positive regulation of Ras protein signal transduction. Located in plasma membrane. Used to study diabetic retinopathy and liver carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase); PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH (S)-nicotine; 1,2-dichlorobenzene; 1-naphthyl isothiocyanate.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24070
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
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196.291M196.292M196.293M196.294M196.295M196.296M196.297M196.298M196.299M196.300M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions