Predicted to enable several functions, including GTPase activity; guanyl ribonucleotide binding activity; and phospholipase C activator activity. Involved in several processes, including Ras protein signal transduction; positive regulation of DNA replication; and positive regulation of ERK1 and ERK2 cascade. Acts upstream of or within positive regulation of Ras protein signal transduction. Located in plasma membrane. Used to study diabetic retinopathy and liver carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase).
RGD Description
Predicted to enable several functions, including GTPase activity; guanyl ribonucleotide binding activity; and phospholipase C activator activity. Involved in several processes, including Ras protein signal transduction; cellular senescence; and positive regulation of ERK1 and ERK2 cascade. Acts upstream of or within positive regulation of Ras protein signal transduction. Located in plasma membrane. Used to study diabetic retinopathy and liver carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase); PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH (S)-nicotine; 1,2-dichlorobenzene; 1-naphthyl isothiocyanate.