Species

Rattus norvegicus

Symbol

Hsd17b7

Name

hydroxysteroid (17-beta) dehydrogenase 7

Synonyms

17-beta-HSD 7
17-beta-hydroxysteroid dehydrogenase 7

Biotype

protein coding gene

Automated Description

Enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity and prolactin receptor binding activity. Involved in several processes, including estrogen biosynthetic process; response to estradiol; and response to prolactin. Predicted to be located in endoplasmic reticulum and mitochondrion. Predicted to be active in endoplasmic reticulum membrane. Biomarker of polycystic ovary syndrome. Orthologous to human HSD17B7 (hydroxysteroid 17-beta dehydrogenase 7).

RGD Description

Enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity and prolactin receptor binding activity. Involved in several processes, including estrogen biosynthetic process; response to estradiol; and response to prolactin. Predicted to be located in endoplasmic reticulum and mitochondrion. Predicted to be active in endoplasmic reticulum membrane. Biomarker of polycystic ovary syndrome. Orthologous to human HSD17B7 (hydroxysteroid 17-beta dehydrogenase 7); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-naphthyl isothiocyanate; 17beta-estradiol.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR44442

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

Cell color indicative of annotation volume

Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
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Sequence Feature Viewer

Genome location

Chr13:82170079...82190018 - (19.94 kb)

Assembly version

mRatBN7.2

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Hsd17b7 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection method	Source	Reference
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Genetic Interactions

Hsd17b7 role	Hsd17b7 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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