Version: 8.0.0
Date: Tue Jan 28 2025
Insr
Rattus norvegicusRGD:2917
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Insr

Species
Rattus norvegicus
Symbol
Insr
Name
insulin receptor
Synonyms
  • insulin receptor preproprotein
  • IR
Biotype
protein coding gene
Automated Description
Enables several functions, including enzyme binding activity; insulin binding activity; and insulin receptor activity. Involved in several processes, including neuron projection organization; protein phosphorylation; and regulation of primary metabolic process. Located in several cellular components, including dendrite membrane; external side of plasma membrane; and neuronal cell body membrane. Used to study chronic kidney disease; diabetic neuropathy; liver disease (multiple); and type 2 diabetes mellitus. Biomarker of several diseases, including Alzheimer's disease; diabetes mellitus (multiple); hepatic encephalopathy; liver disease (multiple); and short bowel syndrome. Human ortholog(s) of this gene implicated in Donohue syndrome; glucose metabolism disease (multiple); and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor).
RGD Description
Enables several functions, including enzyme binding activity; insulin binding activity; and insulin receptor activity. Involved in several processes, including negative regulation of macromolecule metabolic process; neuron projection organization; and protein phosphorylation. Located in several cellular components, including dendrite membrane; external side of plasma membrane; and neuronal cell body membrane. Used to study chronic kidney disease; diabetic neuropathy; liver disease (multiple); and type 2 diabetes mellitus. Biomarker of several diseases, including Alzheimer's disease; diabetes mellitus (multiple); hepatic encephalopathy; liver disease (multiple); and short bowel syndrome. Human ortholog(s) of this gene implicated in Donohue syndrome; glucose metabolism disease (multiple); and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor); PARTICIPATES IN altered leptin system pathway; insulin signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (+)-catechin; (3,4-dihydroxyphenyl)acetic acid; (S)-nicotine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24416
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Download all Alleles/Variants for all genes of the species

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            1.20M1.22M1.24M1.26M1.28M1.30M1.32M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Insr molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Insr role
              Insr genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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