Enables several functions, including SH2 domain binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; regulation of insulin receptor signaling pathway; and regulation of peptide hormone secretion. Part of insulin receptor complex. Used to study end stage renal disease; obesity; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; metabolic dysfunction-associated steatotic liver disease; and osteoporosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; type 2 diabetes mellitus; and uterine fibroid. Orthologous to human IRS1 (insulin receptor substrate 1).
RGD Description
Enables several functions, including SH2 domain binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; regulation of insulin receptor signaling pathway; and regulation of peptide hormone secretion. Part of insulin receptor complex. Used to study end stage renal disease; obesity; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; metabolic dysfunction-associated steatotic liver disease; and osteoporosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; type 2 diabetes mellitus; and uterine fibroid. Orthologous to human IRS1 (insulin receptor substrate 1); PARTICIPATES IN insulin signaling pathway; insulin-like growth factor signaling pathway; interleukin-2 signaling pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 17beta-estradiol.