Gene

Irs1

Species
Rattus norvegicus
Symbol
Irs1
Name
insulin receptor substrate 1
Synonyms
  • IRS-1
  • IRS1IRM
Biotype
protein coding gene
Automated Description
Enables several functions, including SH2 domain binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; regulation of insulin receptor signaling pathway; and regulation of peptide hormone secretion. Part of insulin receptor complex. Used to study end stage renal disease; obesity; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; metabolic dysfunction-associated steatotic liver disease; and osteoporosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; type 2 diabetes mellitus; and uterine fibroid. Orthologous to human IRS1 (insulin receptor substrate 1).
RGD Description
Enables several functions, including SH2 domain binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; regulation of insulin receptor signaling pathway; and regulation of peptide hormone secretion. Part of insulin receptor complex. Used to study end stage renal disease; obesity; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; metabolic dysfunction-associated steatotic liver disease; and osteoporosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; type 2 diabetes mellitus; and uterine fibroid. Orthologous to human IRS1 (insulin receptor substrate 1); PARTICIPATES IN insulin signaling pathway; insulin-like growth factor signaling pathway; interleukin-2 signaling pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 17beta-estradiol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10614
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
83.55M83.56M83.57M83.58M83.59M83.60M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions