Predicted to enable G protein-coupled receptor binding activity and integrin binding activity. Predicted to contribute to insulin-like growth factor I binding activity and neuregulin binding activity. Predicted to be involved in several processes, including hemidesmosome assembly; integrin-mediated signaling pathway; and skin morphogenesis. Predicted to act upstream of or within several processes, including filopodium assembly; peripheral nervous system myelin formation; and trophoblast cell migration. Located in cell cortex. Is active in glutamatergic synapse and postsynaptic membrane. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGB4 (integrin subunit beta 4).
RGD Description
Predicted to enable G protein-coupled receptor binding activity and integrin binding activity. Predicted to contribute to insulin-like growth factor I binding activity and neuregulin binding activity. Predicted to be involved in several processes, including hemidesmosome assembly; integrin-mediated signaling pathway; and skin morphogenesis. Predicted to act upstream of or within several processes, including filopodium assembly; peripheral nervous system myelin formation; and trophoblast cell migration. Located in cell cortex. Is active in glutamatergic synapse and postsynaptic membrane. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGB4 (integrin subunit beta 4); PARTICIPATES IN integrin mediated signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.