Species

Rattus norvegicus

Symbol

Itgb7

Name

integrin subunit beta 7

Synonyms

integrin beta 7
integrin beta-7

Biotype

protein coding gene

Automated Description

Predicted to enable integrin binding activity. Predicted to be involved in several processes, including integrin-mediated signaling pathway; leukocyte tethering or rolling; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within T cell migration. Predicted to be part of integrin alpha4-beta7 complex. Predicted to be active in cell surface and focal adhesion. Orthologous to human ITGB7 (integrin subunit beta 7).

RGD Description

Predicted to enable integrin binding activity. Predicted to be involved in several processes, including integrin-mediated signaling pathway; leukocyte tethering or rolling; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within T cell migration. Predicted to be part of integrin alpha4-beta7 complex. Predicted to be active in cell surface and focal adhesion. Orthologous to human ITGB7 (integrin subunit beta 7); PARTICIPATES IN E-cadherin signaling pathway; integrin mediated signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR10082

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

Phenotype Term	Annotation details	References
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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

Cell color indicative of annotation volume

Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
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Sequence Feature Viewer

Genome location

Chr7:133347927...133364955 - (17.03 kb)

Assembly version

mRatBN7.2

Viewer Help

Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Itgb7 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection method	Source	Reference
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Genetic Interactions

Itgb7 role	Itgb7 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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