Version: 8.0.0
Date: Tue Jan 28 2025
Jag1
Rattus norvegicusRGD:2937
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Jag1

Species
Rattus norvegicus
Symbol
Jag1
Name
jagged canonical Notch ligand 1
Synonyms
  • jagged 1
  • protein jagged-1
Biotype
protein coding gene
Automated Description
Enables Notch binding activity and receptor ligand activity. Involved in several processes, including animal organ regeneration; inner ear auditory receptor cell differentiation; and positive regulation of cardiac epithelial to mesenchymal transition. Predicted to be located in adherens junction and apical plasma membrane. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in Alagille syndrome; Charcot-Marie-Tooth disease; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1).
RGD Description
Enables Notch binding activity and receptor ligand activity. Involved in several processes, including animal organ regeneration; inner ear auditory receptor cell differentiation; and positive regulation of cardiac epithelial to mesenchymal transition. Predicted to be located in adherens junction and apical plasma membrane. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in Alagille syndrome; Charcot-Marie-Tooth disease; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1); PARTICIPATES IN Notch signaling pathway; Alagille syndrome pathway; altered Notch signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24049
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Jag1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Jag1 role
            Jag1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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