Version: 8.0.0Date: Tue Jan 28 2025
Gene
Kcna1
- Species
- Rattus norvegicus
- Symbol
- Kcna1
- Name
- potassium voltage-gated channel subfamily A member 1
- Synonyms
- IA
- Kcna
- Biotype
- protein coding gene
- Automated Description
- Enables delayed rectifier potassium channel activity; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including nervous system development; neuronal action potential; and neuronal signal transduction. Located in several cellular components, including apical plasma membrane; main axon; and neuronal cell body. Part of voltage-gated potassium channel complex. Is active in calyx of Held; glutamatergic synapse; and synaptic membrane. Used to study epilepsy with generalized tonic-clonic seizures and episodic ataxia type 1. Human ortholog(s) of this gene implicated in episodic ataxia type 1. Orthologous to human KCNA1 (potassium voltage-gated channel subfamily A member 1).
- RGD Description
- Enables delayed rectifier potassium channel activity; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including nervous system development; neuronal action potential; and neuronal signal transduction. Located in several cellular components, including apical plasma membrane; main axon; and neuronal cell body. Part of voltage-gated potassium channel complex. Is active in calyx of Held; glutamatergic synapse; and synaptic membrane. Used to study episodic ataxia type 1 and visual epilepsy. Human ortholog(s) of this gene implicated in episodic ataxia type 1. Orthologous to human KCNA1 (potassium voltage-gated channel subfamily A member 1); INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; acrylamide.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11537
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
Phenotype Term | Annotation details | References |
|---|---|---|
| No records match query. Try removing filters. | ||
Showing 0 - 0 of 0 rows
per page
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | |||||||
Showing 0 - 0 of 0 rows
per page
Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | |||||||
Showing 0 - 0 of 0 rows
per page
Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
|---|---|---|---|---|---|
| No records match query. Try removing filters. | |||||
Showing 0 - 0 of 0 rows
per page
Sequence Feature Viewer
- Genome location
- Chr4:159464188...159472905 - (8.72 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.