Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts)
Biotype
protein coding gene
Automated Description
Enables copper ion binding activity and protein-lysine 6-oxidase activity. Involved in extracellular matrix organization; response to steroid hormone; and response to xenobiotic stimulus. Acts upstream of or within cell chemotaxis; platelet-derived growth factor receptor-beta signaling pathway; and protein oxidation. Located in extracellular matrix. Used to study abdominal aortic aneurysm; arteriosclerosis; coronary artery disease; coronary restenosis; and hypertension. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Menkes disease; colon adenocarcinoma; hypertension; and thoracic aortic aneurysm. Orthologous to human LOX (lysyl oxidase).
RGD Description
Enables copper ion binding activity and protein-lysine 6-oxidase activity. Involved in extracellular matrix organization; response to steroid hormone; and response to xenobiotic stimulus. Acts upstream of or within cell chemotaxis; platelet-derived growth factor receptor-beta signaling pathway; and protein oxidation. Located in extracellular matrix. Used to study abdominal aortic aneurysm; arteriosclerosis; coronary artery disease; coronary restenosis; and hypertension. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Menkes disease; colon adenocarcinoma; hypertension; and thoracic aortic aneurysm. Orthologous to human LOX (lysyl oxidase); PARTICIPATES IN hypertension pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.