Version: 8.0.0Date: Tue Jan 28 2025
Gene
Smad3
- Species
- Rattus norvegicus
- Symbol
- Smad3
- Name
- SMAD family member 3
- Synonyms
- MAD (mothers against decapentaplegic Drosophila) homolog 3
- MAD (mothers against decapentaplegic, Drosophila) homolog 3
- Biotype
- protein coding gene
- Automated Description
- Enables several functions, including DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cellular component biogenesis; and regulation of macromolecule metabolic process. Located in nucleus. Part of transcription regulator complex. Used to study pre-malignant neoplasm. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic cancer. Orthologous to human SMAD3 (SMAD family member 3).
- RGD Description
- Enables several functions, including DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; positive regulation of hydrolase activity; and regulation of gene expression. Located in nucleus. Part of transcription regulator complex. Used to study pre-malignant neoplasm. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic cancer. Orthologous to human SMAD3 (SMAD family member 3); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; INTERACTS WITH (-)-ephedrine; (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR13703
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr8:64110039...64236960 - (126.92 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.