Gene

Mbp

Species
Rattus norvegicus
Symbol
Mbp
Name
myelin basic protein
Synonyms
  • Golli-Mbp
  • MBP S
Biotype
protein coding gene
Automated Description
A structural constituent of myelin sheath. Involved in several processes, including negative regulation of axonogenesis; response to progesterone; and response to tumor necrosis factor. Located in cell surface and compact myelin. Used to study demyelinating disease. Biomarker of Huntington's disease; brain disease (multiple); diabetic neuropathy; hypothyroidism; and schizophrenia. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human MBP (myelin basic protein).
RGD Description
A structural constituent of myelin sheath. Involved in several processes, including negative regulation of axonogenesis; response to progesterone; and response to tumor necrosis factor. Located in cell surface and compact myelin. Used to study demyelinating disease. Biomarker of Huntington's disease; brain disease (multiple); diabetic neuropathy; hypothyroidism; and schizophrenia. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human MBP (myelin basic protein); INTERACTS WITH (20S)-20-hydroxypregn-4-en-3-one; (S)-nicotine; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11429
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
75.86M75.87M75.88M75.89M75.90M75.91M75.92M75.93M75.94M75.95M75.96M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions