Version: 8.0.0
Date: Tue Jan 28 2025
Pde4a
Rattus norvegicusRGD:3279
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Pde4a

Species
Rattus norvegicus
Symbol
Pde4a
Name
phosphodiesterase 4A
Synonyms
  • 3',5'-cyclic-AMP phosphodiesterase 4A
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Biotype
protein coding gene
Automated Description
Enables 3',5'-cyclic-AMP phosphodiesterase activity and TPR domain binding activity. Involved in cAMP catabolic process; modulation of chemical synaptic transmission; and response to xenobiotic stimulus. Located in cytosol and perinuclear region of cytoplasm. Is active in Schaffer collateral - CA1 synapse. Biomarker of brucellosis and visual epilepsy. Orthologous to human PDE4A (phosphodiesterase 4A).
RGD Description
Enables 3',5'-cyclic-AMP phosphodiesterase activity. Involved in cAMP catabolic process; modulation of chemical synaptic transmission; and response to xenobiotic stimulus. Located in cytosol and perinuclear region of cytoplasm. Is active in Schaffer collateral - CA1 synapse. Biomarker of brucellosis and visual epilepsy. Orthologous to human PDE4A (phosphodiesterase 4A); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 3,4-methylenedioxymethamphetamine; 3-Methoxynobiletin; 3H-1,2-dithiole-3-thione.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11347
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            19.70M19.71M19.72M19.73M19.74M19.75M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Pde4a molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Pde4a role
              Pde4a genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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