Version: 8.0.0
Date: Tue Jan 28 2025
Plcb1
Rattus norvegicusRGD:3344
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Plcb1

Species
Rattus norvegicus
Symbol
Plcb1
Name
phospholipase C beta 1
Synonyms
  • 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
Biotype
protein coding gene
Automated Description
Enables calcium ion binding activity; identical protein binding activity; and phosphatidylinositol phospholipase C activity. Involved in several processes, including cellular response to glyceraldehyde; cellular response to ionomycin; and learning or memory. Predicted to be located in chromatin and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including GABA-ergic synapse; nuclear speck; and postsynaptic cytosol. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in Alzheimer's disease; developmental and epileptic encephalopathy 12; and myelodysplastic syndrome. Orthologous to human PLCB1 (phospholipase C beta 1).
RGD Description
Enables calcium ion binding activity; identical protein binding activity; and phosphatidylinositol phospholipase C activity. Involved in several processes, including cellular response to glyceraldehyde; cellular response to ionomycin; and learning or memory. Predicted to be located in chromatin and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including GABA-ergic synapse; nuclear speck; and postsynaptic cytosol. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in Alzheimer's disease; developmental and epileptic encephalopathy 12; and myelodysplastic syndrome. Orthologous to human PLCB1 (phospholipase C beta 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; 1-(3-chlorophenyl)piperazine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10336
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Plcb1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Plcb1 role
            Plcb1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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