Version: 8.0.0
Date: Tue Jan 28 2025
Pparg
Rattus norvegicusRGD:3371
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Pparg

Species
Rattus norvegicus
Symbol
Pparg
Name
peroxisome proliferator-activated receptor gamma
Synonyms
  • nuclear receptor subfamily 1 group C member 3
  • peroxisome proliferator activated receptor gamma
Biotype
protein coding gene
Automated Description
Enables several functions, including nuclear estrogen receptor binding activity; protein phosphatase binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to hyperoxia; positive regulation of cell differentiation; and positive regulation of metabolic process. Acts upstream of or within negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of connective tissue replacement involved in inflammatory response wound healing; and positive regulation of adiponectin secretion. Located in perinuclear region of cytoplasm. Used to study several diseases, including acute kidney failure; artery disease (multiple); glomerulosclerosis; pancreatitis; and transient cerebral ischemia. Biomarker of several diseases, including alcoholic cardiomyopathy; diabetic encephalopathy; hyperandrogenism; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; lipodystrophy (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma).
RGD Description
Enables several functions, including nuclear estrogen receptor binding activity; protein phosphatase binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to hyperoxia; cellular response to prostaglandin E stimulus; and positive regulation of cell differentiation. Acts upstream of or within negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of connective tissue replacement involved in inflammatory response wound healing; and positive regulation of adiponectin secretion. Located in perinuclear region of cytoplasm. Used to study several diseases, including acute kidney failure; artery disease (multiple); glomerulosclerosis; pancreatitis; and transient cerebral ischemia. Biomarker of several diseases, including alcoholic cardiomyopathy; diabetic encephalopathy; hyperandrogenism; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; lipodystrophy (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma); PARTICIPATES IN DNA modification pathway; Wnt signaling, non-canonical pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH (+)-catechin; (+)-schisandrin B; (25R)-cholest-5-ene-3beta,26-diol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24082
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Pparg molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Pparg role
            Pparg genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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