Version: 8.0.0Date: Tue Jan 28 2025
Gene
Prkcb
- Species
- Rattus norvegicus
- Symbol
- Prkcb
- Name
- protein kinase C, beta
- Synonyms
- PKC-beta
- Pkcb
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable several functions, including nuclear androgen receptor binding activity; nuclear receptor coactivator activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of insulin receptor signaling pathway; positive regulation of odontogenesis of dentin-containing tooth; and response to vitamin D. Located in brush border membrane; centrosome; and cytosol. Used to study hyperglycemia; hypertension; and silicosis. Biomarker of congestive heart failure; obesity; and status epilepticus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta).
- RGD Description
- Predicted to enable several functions, including nuclear androgen receptor binding activity; nuclear receptor coactivator activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of insulin receptor signaling pathway; positive regulation of odontogenesis of dentin-containing tooth; and response to vitamin D. Located in brush border membrane; centrosome; and cytosol. Used to study hyperglycemia; hypertension; and silicosis. Biomarker of congestive heart failure; obesity; and status epilepticus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta); PARTICIPATES IN insulin signaling pathway; interleukin-2 signaling pathway; protein kinase C (PKC) signaling pathway; INTERACTS WITH (+)-pilocarpine; (9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione; 1-naphthyl isothiocyanate.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24356
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr1:176832173...177163539 + (331.37 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.