Gene

Ptgis

Species
Rattus norvegicus
Symbol
Ptgis
Name
prostaglandin I2 synthase
Synonyms
  • hydroperoxy icosatetraenoate dehydratase
  • PGIS
Biotype
protein coding gene
Automated Description
Enables prostaglandin-I synthase activity. Involved in several processes, including cellular response to estradiol stimulus; negative regulation of smooth muscle cell proliferation; and prostaglandin biosynthetic process. Predicted to be located in caveola; endoplasmic reticulum membrane; and nucleus. Used to study cerebral infarction; congestive heart failure; ischemia (multiple); and pulmonary hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); colorectal adenoma; limb ischemia; and primary pulmonary hypertension. Orthologous to human PTGIS (prostaglandin I2 synthase).
RGD Description
Enables prostaglandin-I synthase activity. Involved in several processes, including cellular response to estradiol stimulus; negative regulation of smooth muscle cell proliferation; and prostaglandin biosynthetic process. Predicted to be located in caveola; endoplasmic reticulum membrane; and nucleus. Used to study cerebral infarction; congestive heart failure; ischemia (multiple); and pulmonary hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); colorectal adenoma; limb ischemia; and primary pulmonary hypertension. Orthologous to human PTGIS (prostaglandin I2 synthase); PARTICIPATES IN prostacyclin biosynthetic pathway; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH (R)-carnitine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24306
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensPTGIS10 of 10YesYes  
Mus musculusPtgis9 of 9YesYes   
Xenopus tropicalisptgis2 of 9YesYes   
Danio rerioptgis9 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Cyp8b1250657412 of 9 

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

No mapped variant information available
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_051338.1:g.155945254G>Avariant
SNP
  • intron variant
NC_051338.1:g.155931850A>Cvariant
NC_051338.1:g.155950971A>Gvariant
NC_051338.1:g.155943463C>Tvariant
SNP
  • splice region variant
NC_051338.1:g.155944137G>Tvariant
SNP
  • intron variant
NC_051338.1:g.155951584G>Tvariant
SNP
  • missense variant
NC_051338.1:g.155930364G>Avariant
SNP
  • intron variant
NC_051338.1:g.155951131C>Tvariant
NC_051338.1:g.155931135A>Gvariant
SNP
  • intron variant
NC_051338.1:g.155950672A>Gvariant
Showing 1 - 10 of 173 rows
per page

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
155.920M155.925M155.930M155.935M155.940M155.945M155.950M155.955M155.960M155.965M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

1 interactor gene based on 1 annotation
Ptgis molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Mapk11Mus musculus
protein
  • proximity labelling technology
PMID:31505169
Showing 1 - 1 of 1 rows
per page

Genetic Interactions

No data available