Gene

Sftpa1

Species
Rattus norvegicus
Symbol
Sftpa1
Name
surfactant protein A1
Synonyms
  • LOC100364823
  • LOC102557073
Biotype
protein coding gene
Automated Description
Predicted to enable carbohydrate binding activity and metal ion binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to nitric oxide; and response to vitamin A. Located in extracellular space and multivesicular body. Biomarker of asthma; congenital diaphragmatic hernia; lung disease (multiple); and obesity. Human ortholog(s) of this gene implicated in lung disease (multiple) and respiratory syncytial virus infectious disease. Orthologous to several human genes including SFTPA1 (surfactant protein A1).
RGD Description
Predicted to enable carbohydrate binding activity and metal ion binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to nitric oxide; and response to vitamin A. Located in extracellular space and multivesicular body. Biomarker of asthma; congenital diaphragmatic hernia; lung disease (multiple); and obesity. Human ortholog(s) of this gene implicated in lung disease (multiple) and respiratory syncytial virus infectious disease. Orthologous to several human genes including SFTPA1 (surfactant protein A1); PARTICIPATES IN forkhead class A signaling pathway; phagocytosis pathway; INTERACTS WITH (R)-lipoic acid; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22803
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensSFTPA110 of 10YesYes  
Homo sapiensSFTPA29 of 10NoYes  
Mus musculusSftpa19 of 9YesYes   
Xenopus tropicalissftpa3 of 9YesYes   
Drosophila melanogasterlectin-28C2 of 9YesYes   
Drosophila melanogasterCG158182 of 9YesYes   
Drosophila melanogasterlectin-24A2 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Sftpd126947365 of 9 
Colec11228343304 of 9 
Mbl2325749353 of 9 
Colec10425343314 of 9 
Mbl1521852393 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
mRatBN7.2
Viewer Help
17.0085M17.0090M17.0095M17.0100M17.0105M17.0110M17.0115M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_051351.1:g.17009337C>Tvariant
SNP
  • intron variant
NC_051351.1:g.17009245C>Tvariant
SNP
  • synonymous variant
NC_051351.1:g.17010774G>Tvariant
SNP
  • missense variant
NC_051351.1:g.17008283T>Cvariant
SNP
  • intron variant
NC_051351.1:g.17011311G>Avariant
SNP
  • 3 prime UTR variant
NC_051351.1:g.17011533T>Cvariant
SNP
  • 3 prime UTR variant
NC_051351.1:g.17008524A>Gvariant
SNP
  • intron variant
NC_051351.1:g.17010409G>Avariant
SNP
  • intron variant
NC_051351.1:g.17008298C>Tvariant
SNP
  • intron variant
NC_051351.1:g.17008284G>Avariant
SNP
  • intron variant
Showing 1 - 10 of 17 rows
per page

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
17.0085M17.0090M17.0095M17.0100M17.0105M17.0110M17.0115M

Sequence Details

Transcript: Mode:

Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

1 interactor gene based on 2 annotations
Sftpa1 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Prdx6Rattus norvegicus
protein
  • affinity chromatography technology
PMID:16330552
protein
Prdx6Rattus norvegicus
protein
  • affinity chromatography technology
PMID:16330552
Showing 1 - 2 of 2 rows
per page

Genetic Interactions

No data available