Species

Rattus norvegicus

Symbol

Sgk1

Name

serum/glucocorticoid regulated kinase 1

Synonyms

serine/threonine protein kinase SGK
serine/threonine-protein kinase Sgk1

Biotype

protein coding gene

Automated Description

Enables 3-phosphoinositide-dependent protein kinase binding activity; protein serine/threonine kinase activity; and tau protein binding activity. Involved in several processes, including learning or memory; negative regulation of microtubule polymerization; and positive regulation of dendrite morphogenesis. Acts upstream of or within cellular response to insulin stimulus; positive regulation of sodium ion transport; and regulation of protein localization. Located in perinuclear region of cytoplasm. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SGK1 (serum/glucocorticoid regulated kinase 1).

RGD Description

Enables 3-phosphoinositide-dependent protein kinase binding activity; protein serine/threonine kinase activity; and tau protein binding activity. Involved in several processes, including learning or memory; negative regulation of microtubule polymerization; and positive regulation of dendrite morphogenesis. Acts upstream of or within cellular response to insulin stimulus; positive regulation of sodium ion transport; and regulation of protein localization. Located in perinuclear region of cytoplasm. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SGK1 (serum/glucocorticoid regulated kinase 1); PARTICIPATES IN glucocorticoid signaling pathway; insulin signaling pathway; mTOR signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 11-dehydrocorticosterone; 17alpha-ethynylestradiol.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR24351

No data available

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

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Disease Associations

Cell color indicative of annotation volume

Gene	Association	Disease Qualifier	Disease	Evidence	Source	Based On	References
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Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Download all Alleles/Variants for all genes of the species

Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
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Sequence Feature Viewer

Genome location

Chr1:22980257...23098283 - (118.03 kb)

Assembly version

mRatBN7.2

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Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Sgk1 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
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Genetic Interactions

Sgk1 role	Sgk1 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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