Version: 8.1.0
Date: Fri Apr 18 2025
Shh
Rattus norvegicusRGD:3673
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Shh

Species
Rattus norvegicus
Symbol
Shh
Name
sonic hedgehog signaling molecule
Synonyms
  • shh unprocessed N-terminal signaling and C-terminal autoprocessing domains
  • ShhNC
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including cholesterol-protein transferase activity; laminin-1 binding activity; and metal ion binding activity. Involved in several processes, including nervous system development; positive regulation of cell differentiation; and reproductive structure development. Acts upstream of or within ventral spinal cord interneuron specification. Located in several cellular components, including dendrite; neuronal cell body; and synaptic vesicle. Is active in several cellular components, including glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and postsynapse. Used to study Parkinsonism and myocardial infarction. Biomarker of several diseases, including VACTERL association; chronic kidney disease; esophageal atresia/tracheoesophageal fistula; ocular hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly (multiple). Orthologous to human SHH (sonic hedgehog signaling molecule).
RGD Description
Predicted to enable several functions, including cholesterol-protein transferase activity; laminin-1 binding activity; and metal ion binding activity. Involved in several processes, including nervous system development; positive regulation of cell differentiation; and reproductive structure development. Acts upstream of or within ventral spinal cord interneuron specification. Located in several cellular components, including dendrite; neuronal cell body; and synaptic vesicle. Is active in several cellular components, including glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and postsynapse. Used to study Parkinsonism and myocardial infarction. Biomarker of several diseases, including VACTERL association; chronic kidney disease; esophageal atresia/tracheoesophageal fistula; ocular hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly (multiple). Orthologous to human SHH (sonic hedgehog signaling molecule); PARTICIPATES IN altered Hedgehog signaling pathway; forkhead class A signaling pathway; glypican signaling pathway; INTERACTS WITH (S)-amphetamine; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17beta-estradiol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11889
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Shh molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
          Reference
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            Genetic Interactions

            Shh role
            Shh genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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