Version: 8.0.0Date: Tue Jan 28 2025
Gene
Sod2
- Species
- Rattus norvegicus
- Symbol
- Sod2
- Name
- superoxide dismutase 2
- Synonyms
- manganese superoxide dismutase
- mitochondrial superoxide dismutase 2
- Biotype
- protein coding gene
- Automated Description
- Enables several functions, including manganese ion binding activity; oxygen binding activity; and superoxide dismutase activity. Involved in several processes, including cellular response to ethanol; hydrogen peroxide biosynthetic process; and negative regulation of membrane hyperpolarization. Located in mitochondrial nucleoid. Used to study esophagus adenocarcinoma; hypertension; intestinal disease; and myocardial infarction. Biomarker of several diseases, including adult respiratory distress syndrome; artery disease (multiple); bladder neck obstruction; congenital diaphragmatic hernia; and steatotic liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); cardiomyopathy (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2).
- RGD Description
- Enables several functions, including manganese ion binding activity; oxygen binding activity; and superoxide dismutase activity. Involved in several processes, including cellular response to ethanol; hydrogen peroxide biosynthetic process; and negative regulation of membrane hyperpolarization. Located in mitochondrial nucleoid. Used to study esophagus adenocarcinoma; hypertension; intestinal disease; and myocardial infarction. Biomarker of several diseases, including adult respiratory distress syndrome; artery disease (multiple); bladder neck obstruction; congenital diaphragmatic hernia; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); cardiomyopathy (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2); PARTICIPATES IN hypertension pathway; Huntington's disease pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (+)-sesamin.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11404
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr1:47636528...47645189 - (8.66 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.