Predicted to enable extracellular matrix binding activity; integrin binding activity; and small molecule binding activity. Involved in several processes, including negative regulation of collateral sprouting of intact axon in response to injury; positive regulation of bone resorption; and response to macrophage colony-stimulating factor. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and vesicle. Used to study several diseases, including encephalomyelitis; myocarditis; radiculopathy; renovascular hypertension; and visual epilepsy. Biomarker of autosomal dominant polycystic kidney disease; calcinosis; and glomerulosclerosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1).
RGD Description
Predicted to enable extracellular matrix binding activity; integrin binding activity; and small molecule binding activity. Involved in several processes, including negative regulation of collateral sprouting of intact axon in response to injury; positive regulation of bone resorption; and response to macrophage colony-stimulating factor. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and vesicle. Used to study several diseases, including encephalomyelitis; myocarditis; radiculopathy; renovascular hypertension; and visual epilepsy. Biomarker of autosomal dominant polycystic kidney disease; calcinosis; and glomerulosclerosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1); PARTICIPATES IN diabetic nephropathy pathway; c-Jun N-terminal kinases MAPK signaling pathway; fibroblast growth factor signaling pathway; INTERACTS WITH (R,R)-tramadol; (S)-naringenin; 1,3,5-trinitro-1,3,5-triazinane.